ARI selected to be a member of a prestigious European Commission funded research project

The project is entitled "Gene Activated Matrices for Bone and Cartilage Regeneration in Arthritis".

25 August 2010


The AO Research Institute Davos (ARI) is pleased to announce that they are one of seven participant institutions from six countries taking part in the Gene Activated Matrices for Bone and Cartilage Regeneration in Arthritis (GAMBA) project as part of the Seventh Framework (FP7) Program. The FP7 program comes from the European Community Directorate General for Research and the project group includes two university hospitals, one university, one research institute and 2 small and medium enterprises. For its part in the GAMBA, AO Research Institute Davos will receive 457,800 Euro over three years.

The main objective of this project is to develop a biomimetic implant system using a nanobiotechnological approach that delivers regenerative bioactivity in a temporally and spatially controlled fashion in response to endogenous and external stimuli. In this manner, the system shall respond to and control inflammation and induce cartilage and subchondral bone repair in osteoarthritis-related tissue defects. The implant system shall alter the phenotype of cells in a physiologically meaningful way to elicit the desired therapeutic outcome.

The role of AO Research Institute Davos and co-applicants, Mauro Alini, Ludovic Bouré and David Eglin, within the consortium is to develop and provide biomimetic hydrogels for spatiotemporal control of therapeutic bioactivity on command and demand based on a novel gene activated matrix platform and provide a large preclinical model for identification of the best conditions to repair cartilage and bone.

 This innovative concept is implemented by a multidisciplinary team from leading European institutions combining scientific excellence with a well-structured plan of dissemination, public participation, gender equality and bench-to-market transition. The acceptance of AO Research Institute Davos within this EU funded project confirms the AO Research Institute Davos’s standing as a leading internationally recognised research institute.

Mauro Alini, Ludovic Bouré, David Eglin

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