Award for Mauro Alini

Mauro Alini, Vice-Chair ARI, is the 2015 Winner of the ORS Marshall R Urist, MD Award

06 May 2015

​The AO Research Institute, Davos (ARI) are delighted to announce that Prof Mauro Alini is the 2015 recipient of the ORS Marshall R. Urist, MD Award—the highest award of the Orthopaedic Research Society (ORS). This is the first time an AO Research Institute Davos member has won this award that was created in 1996. This prestigious award honors an investigator who has established him/herself as a cutting-edge researcher in tissue regeneration research and has done so with a sustained ongoing body of focused research in the area of tissue regeneration as it relates to the musculoskeletal system. Mauro will present a modified version of this talk at the AO Trustees Meeting in Thailand in June 2015. AO Research Institute Davos congratulates Mauro on this remarkable achievement.

While this is the ultimate honor within the ORS, AO Research Institute Davos also had a strong representation in ORS, with a number of AO Research Institute Davos members taking part in committee activities, and organising, symposia, workshops and research interest groups. In addition to the AO Foundation being the only non-society member of International Combined Orthopaedic Research Societies (ICORS), the academic excellence of AO Research Institute Davos is being recognised internationally at multiple levels within the field.

Reviewed and accepted symposia

1. Improving the Translational Success of Cell-Based Therapies
Organizers: Jennifer J. Bara, PhD, AO Research Institute
Marietta Herrmann, PhD, AO Research Institute
Geoff Richards, PhD, AO Research Institute

This workshop, addressed the clinical, scientific, and industrial requirements for the successful translation of cell-based therapies into both the clinic and market with an emphasis on educating investigators new to the translational process. By identifying current challenges and ascertaining the perceptions and needs of future investigators, suggestions were made and a white paper will be written to aim to help to improve rates of translational success in the future.

Clinical Considerations for Translational Success  Theodore Miclau, MD, University of California, San Francisco
Scientific Considerations for Translational Success  Christopher H. Evans, PhD, Mayo Clinic
Industrial Considerations for Translational Success  Anthony Ratcliffe, PhD, Synthasome, Inc.

Reviewed and Accepted Workshops

Acute Cartilage Injury: AO Foundation Collaborative Research Project
Organizers: Martin Stoddart, PhD, AO Research Institute
George R. Dodge, PhD, University of Pennsylvania

The repair of acute cartilage injuries is still a significant challenge in orthopeadics. Current methods do not reproducibly result in hyaline like repair tissue, and the repair is often short lived. A more active, yet aging, population is increasing the frequency of injury and the longer term effect of osteoarthritis is becoming more prevalent. The economic burden due to the ever increasing need is enormous. This workshop highlighted the influence of cell, materials and mechanical environment in the repair of cartilage defects. In addition, strategies for screening the large number of potential combinatorial devices were emphasized. Interdisciplinary and international collaborations are needed to bring diverse ideas and technologies to bear. In this workshop the outcome of multidisciplinary, multinational consortium with complementary expertise as a collaborative research project of the AO Foundation was described.

Enhancing the Biology of Cartilage Regeneration  Magali Cucchiarini, PhD, Saarland University Medical Center
In Vitro and In Vivo Screening of Cartilage Repair Products  Robert Mauck, PhD, University of Pennsylvania
Hard and Soft Materials for Articular Cartilage Repair  David Eglin, PhD, AO Research Institute

Other accepted Activities

Good and Bad Animal Models for Orthopaedic Research: Scientific and Ethical Considerations
Organizer: Stephan Zeiter, PhD, AO Research Institute

Objectives: There is a scientific and ethical imperative that clinically most relevant models are used for orthopaedic research. Scientifically, the models should mimic as much as possible the (human) clinical situation. Ethically, according to the 3R principle, the number of animals used should be kept a minimum and potential pain, suffering, or distress should be minimized in all animals used in order to enhance animal welfare.

Research Interest Group: Spine Research Community
Co-organizer: Sibylle Grad, PhD, AO Research Institute

Animal Welfare in Orthopaedic Research: Focus on Refinement and Reduction
Keynote lecture: The Team Approach to Implementing the 3R’s Stephan Zeiter, DVM, PhD, DipECLAM, AO Research Institute Davos

ICORS (International Combined Orthopaedic Research Societies) Update

With ICORS, where the AO Foundation is the only non-society member, Geoff Richards made a proposition to the ICORS International College of Fellows, which was tentatively accepted to be implemented by 2016 at ICORS in Xian. The ICORS steering committee agreed in principal to the fundamental guidelines of the International Fellows program (FIORS) to give public recognition to individuals who have gained a status of excellent professional standing and high achievement in the field of orthopedic research. It is expected that Fellows shall foster professional interactions among each other and ICORS members, with research and medical practitioners, regulatory and legislative offices, and promote public awareness of the profession of orthopaedic research, and promote and encourage professional and continuing education in orthopaedic research.

Core Initiatives of ICORS International College of Fellows

1. Promote the advancement of learning and scholarship and the dissemination of orthopedic research, facilitating its internationalization, including public awareness of the successes and importance.

2. Encourage excellence in orthopedic research and provide independent expert scholarly advice, fostering of the knowledge and capabilities of its members.

3. Provide role models and exemplars of professionalism through highest international standards in scholarship and research.

4. Create a sense of community in the international arena of orthopedic research.

5. Support orthopedic research in developing countries

6. Convene scholarly debate sessions/symposia and activities at ICORS meetings

7. Convene scholarly symposia/workshops at relevant individual ICORS meetings.

AO Research Institute Davos involvement in ORS Committees

Dr Martin Stoddart is Chair ORS Basic Science Education Committee

Prof Mauro Alini is a member of the ORS International Committee

Dr Sibylle Grad is a member of the ORS program committee and co-organizer of the Research Interest Group “The Spine Research Community” at the ORS.

Prof Geoff Richards is a member of ICORS Steering Committee
(International Combined Orthopaedic Research Societies)

The above activities all help to demonstrate that AO Research Institute Davos is both highly respected as an independent research institute and is the most active European team within the leading society of orthopedic research.

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