ARI drives progress in regeneration partnership

ARI helps shape the future of Regenerative Rehabilitation

06 August 2018

Leaders in the field discuss the future direction of Regenerative Rehabilitation, at the Sixth Annual International Symposium on Regenerative Rehabilitation,Pittsburgh (US), November 2017

The AO Research Institute Davos (ARI) is proud to partner with the International Consortium for Regenerative Rehabilitation (ICRR) in its valuable work to improve patient care. Professor Martin Stoddart of the Musculoskeletal Regeneration Program joined the ICRR Leadership Council​ on July 1, and in this new role is ideally placed to promote the clinical implications of orthopedic rehabilitation and mechanobiology.

Active discussion at the annual symposium poster

The next main event is the Seventh Annual International Regenerative Rehabilitation Symposium to be held in Seattle, United States, October 11 to 13, 2018 where Stoddart is an invited speaker.   The ICRR comprises 16 partners from all over the world who have a shared mission 'to bring together leading scientists and clinicians across the domains of regenerative medicine and rehabilitation science to drive the creation and transfer of knowledge associated with the development and translation of technologies that restore function and enhance the quality of life of patients.'

This mission complements the mission statements of the AO Research Institute Davos​ which is 'to advance patient care through innovative orthopedic research and development' and that of the AO Foundation, which is 'promoting excellence in patient care and outcomes in trauma and musculoskeletal disorders.'

The mechanical environment is known to drive the bone healing process, with rigidity leading to direct bone healing, while limited motion leads to indirect bone healing via a cartilage template (callus). 

Sessions bring together a multi-disciplinary audience
with biologists, engineers, medics, and
physiotherapist's all taking part

Regenerative rehabilitation is the convergence and integration of regenerative medicine and physical rehabilitation sciences. Physical therapy (PT) is essential to support the return to function of a damaged or repaired tissue, but the specific effects of PT at a cellular level during regeneration remain largely unexplored. 

Conversely, when thinking of regenerative approaches, the mechanical environment that cells and scaffolds must withstand in orthopedic repair is often regarded as a challenge that needs to be endured or overcome rather than as an opportunity that can be leveraged. 

Regenerative rehabilitation can be used as an approach to translational mechanobiology, where the mechanical cues driving cell differentiation and function are directed by rehabilitation routines to promote repair and regeneration.  ​​​

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